Detailed view for PF3D7_1203000

Basic information

TDR Targets ID: 5078
Plasmodium falciparum, origin recognition complex subunit 1
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 10.0788 | Length (AA): 1189 | MW (Da): 138738 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00004   ATPase family associated with various cellular activities (AAA)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005575   cellular_component  
GO:0005524   ATP binding  
GO:0003688   DNA replication origin binding  
GO:0000166   nucleotide binding  
GO:0017111   nucleoside-triphosphatase activity  
GO:0006270   DNA replication initiation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 16 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
458 1037 1qvr (A) 231 839 12.00 0 0.85 0.34 0.78
771 1114 1fnn (A) 5 351 21.00 0 1 0.61 -1.11
773 1180 1jr3 (A) 4 367 13.00 0 1 0.27 -0.08
416 599 3e15 (A) 24 188 33.00 0.16 1 0.376852 0.79
785 1103 4xgc (A) 569 894 36.00 0 1 0.522893 -0.18
786 1146 1fnn (A) 20 388 19.00 0 1 0.459816 -0.68
786 1186 2v1u (A) 35 399 23.00 0 1 0.365458 0.18
789 1042 1sxj (E) 17 279 21.00 0.22 1 0.242225 0.58
800 962 4xgc (D) 41 207 19.00 0.0034 0.87 0.44669 -0.76
805 1031 3te6 (A) 569 844 28.00 0.0007 1 0.307017 0.05
188 516 4wat (A) 146 499 18.00 0.016 0.07 0.420354 -0.43
424 607 3e15 (A) 24 188 33.00 0.17 1 0.376218 0.79
793 1111 4xgc (A) 569 894 36.00 0 1 0.52 -0.18
794 1154 1fnn (A) 20 388 19.00 0 1 0.477387 -0.68
794 1194 2v1u (A) 35 399 23.00 0 1 0.389804 0.11
812 970 4xgc (D) 45 207 19.00 0.0037 0.97 0.463332 -0.88

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile merozoite, early schizont, early trophozoite, late schizont, late trophozoite, Oocyst, Male Gametocyte. PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 32 hs, gametocyte, late ring. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Sporozoite, Female Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Ring. Zanghi G
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_126808)

Species Accession Gene Product
Arabidopsis thaliana AT1G07270   cell division control protein 6
Arabidopsis thaliana AT2G29680   cell division control 6
Arabidopsis thaliana AT4G12620   origin of replication complex 1B
Arabidopsis thaliana AT4G14700   origin recognition complex subunit 1
Babesia bovis BBOV_IV001900   origin recognition complex subunit 1
Brugia malayi Bm1_27135   Origin recognition complex subunit 1
Brugia malayi Bm1_35980   Cdc6-related protein
Candida albicans CaO19.3000   Origin recognition complex 1 protein
Candida albicans CaO19.10518   Origin recognition complex 1 protein
Candida albicans CaO19.12707   similar to S. cerevisiae CDC6 (YJL194W) component of DNA replication initiation complex
Caenorhabditis elegans CELE_C43E11.10   Protein CDC-6
Caenorhabditis elegans CELE_Y39A1A.12   Protein ORC-1
Cryptosporidium hominis Chro.40491   origin recognition complex subunit 1
Cryptosporidium parvum cgd4_4320   ORC/CDC6 like AAA+ ATpase
Dictyostelium discoideum DDB_G0283073   origin recognition complex subunit 1
Drosophila melanogaster Dmel_CG10667   Origin recognition complex subunit 1
Drosophila melanogaster Dmel_CG5971   CG5971 gene product from transcript CG5971-RA
Echinococcus granulosus EgrG_000830100   cell division control protein 6
Echinococcus granulosus EgrG_000505000   origin recognition complex subunit 1 A
Entamoeba histolytica EHI_105150   hypothetical protein
Entamoeba histolytica EHI_192770   hypothetical protein
Echinococcus multilocularis EmuJ_000830100   cell division control protein 6
Echinococcus multilocularis EmuJ_000505000   origin recognition complex subunit 1 A
Giardia lamblia GL50803_17103   Orc1/CDC6
Homo sapiens 990   cell division cycle 6
Homo sapiens ENSG00000085840   origin recognition complex, subunit 1
Leishmania braziliensis LbrM.28.0040   origin recognition complex subunit 1 (ORC1), putative,cell division cycle 6 (CDC6), putative
Leishmania donovani LdBPK_280030.1   origin recognition complex subunit 1 (ORC1), putative
Leishmania infantum LinJ.28.0030   origin recognition complex subunit 1 (ORC1), putative,cell division cycle 6 (CDC6), putative
Leishmania major LmjF.28.0030   origin recognition complex subunit 1 (ORC1), putative,cell division cycle 6 (CDC6), putative
Leishmania mexicana LmxM.28.0030   origin recognition complex subunit 1 (ORC1), putative,cell division cycle 6 (CDC6), putative
Loa Loa (eye worm) LOAG_03650   hypothetical protein
Loa Loa (eye worm) LOAG_09370   origin recognition complex subunit 1
Mus musculus ENSMUSG00000017499   cell division cycle 6
Mus musculus ENSMUSG00000028587   origin recognition complex, subunit 1
Neospora caninum NCLIV_028910   hypothetical protein
Oryza sativa 4324832   Os01g0856000
Oryza sativa 4340349   Os06g0187000
Plasmodium berghei PBANKA_0602000   origin recognition complex subunit 1, putative
Plasmodium falciparum PF3D7_1203000   origin recognition complex subunit 1
Plasmodium knowlesi PKNH_1302900   origin recognition complex subunit 1, putative
Plasmodium vivax PVX_084195   origin recognition complex subunit 1, putative
Plasmodium yoelii PY05283   origin recognition complex 1 protein
Saccharomyces cerevisiae YJL194W   AAA family ATPase CDC6
Saccharomyces cerevisiae YML065W   origin recognition complex subunit 1
Schistosoma japonicum Sjp_0112370   Conserved hypothetical protein
Schistosoma japonicum Sjp_0301180   ko:K02603 origin recognition complex subunit 1, putative
Schistosoma mansoni Smp_180380   origin recognition complex subunit
Schistosoma mansoni Smp_145740   cdc6
Schmidtea mediterranea mk4.010991.00   Origin recognition complex subunit 1
Schmidtea mediterranea mk4.007594.00   Origin recognition complex subunit 1
Schmidtea mediterranea mk4.001684.02   Cell division control protein 6 homolog
Trypanosoma brucei gambiense Tbg972.11.8220   origin recognition complex subunit 1 (ORC1), putative,cell division cycle 6 (CDC6), putative
Trypanosoma brucei Tb927.11.7216   origin recognition complex subunit 1 (ORC1), putative
Trypanosoma congolense TcIL3000.11.7820   origin recognition complex subunit 1 (ORC1), putative
Trypanosoma congolense TcIL3000_0_58610   origin recognition complex subunit 1 (ORC1), putative
Trypanosoma cruzi TcCLB.508239.10   origin recognition complex subunit 1 (ORC1), putative
Trypanosoma cruzi TcCLB.511159.20   origin recognition complex subunit 1 (ORC1), putative
Toxoplasma gondii TGME49_283900   ATPase, AAA family protein
Theileria parva TP03_0470   origin recognition complex 1 protein, putative
Trichomonas vaginalis TVAG_340580   origin recognition complex subunit, putative
Trichomonas vaginalis TVAG_376490   CDC6, putative

Essentiality

PF3D7_1203000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.5110 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.5110 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.5110 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.5110 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C43E11.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_C43E11.10 Caenorhabditis elegans larval arrest wormbase
CELE_C43E11.10 Caenorhabditis elegans larval lethal wormbase
CELE_C43E11.10 Caenorhabditis elegans slow growth wormbase
CELE_C43E11.10 Caenorhabditis elegans sterile wormbase
CELE_Y39A1A.12 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y39A1A.12 Caenorhabditis elegans larval arrest wormbase
CELE_Y39A1A.12 Caenorhabditis elegans larval lethal wormbase
CELE_Y39A1A.12 Caenorhabditis elegans sterile wormbase
YJL194W Saccharomyces cerevisiae inviable yeastgenome
YML065W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0602000 Plasmodium berghei Essential plasmo
TGME49_283900 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_1203000 (Plasmodium falciparum), origin recognition complex subunit 1
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